Toxicological in vivo studies of an oral insulin nanosystem
نویسندگان
چکیده
منابع مشابه
In vivo evaluation of physiological efficacy of insulin-loaded nanoliposomes prepared for oral delivery
Introduction: Oral delivery is the most favorable route for insulin administration. The aim of this study was to generate new chitosan coated insulin nanoliposomes and then to assess the physiological efficacy of these nanoliposomes after oral administration in diabetic rabbits. Methods: Nanoliposomes with negative surface charge encapsulating insulin were prepared by reverse phase evaporat...
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Insulin-loaded biodegradable chitosan nanoparticle was prepared by the polyelec-trolyte complex formation method. The prepared nanoparticles were in the size of 110 nm and had high entrapment (91.0%) capacity. The transdermal nanoinsulin was characterized by in vivo hypoglycemic effects. Plasma glucose was decreased to the range of 80.34 to 96.74 mg/dl, and insulin levels were in...
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15 صفحه اولin vivo evaluation of physiological efficacy of insulin-loaded nanoliposomes prepared for oral delivery
introduction: oral delivery is the most favorable route for insulin administration. the aim of this study was to generate new chitosan coated insulin nanoliposomes and then to assess the physiological efficacy of these nanoliposomes after oral administration in diabetic rabbits. methods: nanoliposomes with negative surface charge encapsulating insulin were prepared by reverse phase evaporation ...
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Calvacin is a potent, antitumor mucoprotein which is cumulative in effect and which causes a prolonged intoxication characterized by anorexia and extreme weight loss. It induces a wide spectrum of lesions in experimental mammals. The more promi nent include hepatic necrosis, biliary obstruction, renal tubular necrosis, fibrinoid degeneration, myofibrillar necrosis in cardiac and skeletal muscle...
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ژورنال
عنوان ژورنال: Toxicology Letters
سال: 2007
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2007.05.250